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Anabolic androgenic steroid abuse can lead to serious cardiovascular and psychiatric adverse reactions (see DRUG ABUSE AND DEPENDENCE)with mortality. The risk of death is higher in older age groups. Risk-increasing drugs may lead to increased risk-reducing drugs and to a reduction in drug control.Dietary supplements may cause serious and even fatal cardiac arrhythmias (see PRECAUTIONS).Drugs that may interact with this drug include a number of drugs and vitamins that can interfere with the action of TNG-interacting hormones. There are also drugs or vitamins that may interfere with certain medications. If you take any one of these drugs or supplements, contact your doctor or pharmacist right away to discuss the most appropriate actions.Drug interactions that can affect the metabolism of TNG-interacting hormones include certain antibiotics, antiarrhythmics, and certain antiarrhythmic drugs. Many people who take steroids may use these drugs to treat their symptoms and reduce their risk of developing these side effects. Before you start taking TNG-interacting hormones, ask your doctor or pharmacist about your medical history, if you have any questions.Carcinogenesis, Mutagenesis, Impairment of FertilityStudies of body parts that are typically affected by steroid hormones have not shown any increase or increase in cancer in male and female rats, which have been injected with testosterone or TNG-interacting hormones (including testosterone to suppress bone growth in aging rats).Studies of human cells in which TNG-interacting hormones are altered may not show tumor growth or cause tumor formation in humans.Although no one carcinogen has been identified in rats exposed to high doses of testosterone or to T-REX, there are risks for male and female rats from increased risk of male prostate cancers, thyroid tumors, and other cancers (see WARNINGS and DRUG INTERACTIONS).If you become pregnant while taking TNG-interacting hormones, tell your doctor or pharmacist right away.Liver and PancreasHormone replacement therapy reduces cholesterol in people with type 2 diabetes while increasing serum cholesterol, which may increase the risk for developing diabetes and kidney failure.People who are taking HRT should discuss the safety of their medications with their health care provider so that the care can focus on the benefits of HRT as opposed to the risks, since the risks for serious complications, especially blood clots (thrombosis), appear to be higher with HRT than if the medication is taken without an additional prescription.Your doctor shouldRelated Article: